Arkansas, 1999: Health care workers are over- worked and underpaid. That’s something nurse Mandy could write volumes about, especially now that she’s facing another twelve-hour shift. Two things brighten up the grouchy cynic’s dreary days: having free access to drugs in the hospital and selling the organs of its deceased to the mafia. When her idiot cousin goes and misplaces a kidney—prompting the gangsters to waltz in with guns blazing—and a serial killer is transferred to her ward to top things off, Mandy’s world implodes. 12 Hour Shift sets off a firework of dirty jokes, while a formidable ensemble cast around Angela Bettis—including a fantastic David Arquette—shifts things into high gear.